ISSN 2380-2995 (Online)
ISSN 2380-2987 (Print)


Ronald W. Lindsey, MD
Zbigniew Gugala, MD, PhD


Is Aspirin Best Choice Today for Prophylaxis Against Venous Thromboembolism after Orthopedic Surgery?

Mayukh K. Sarkar, PhD; Michael Laposata, MD, PhD

Department of Pathology, University of Texas Medical Branch; Galveston, TX, USA

Corresponding Author:
Michael Laposata, MD, PhD
Department of Pathology
University of Texas Medical Branch
301 University Blvd
Galveston, TX 77555, USA



Recommendations for prophylaxis to prevent thrombosis in patients undergoing orthopedic surgery have been rapidly evolving, particularly with the FDA approval of new direct oral anticoagulants for this purpose. Over the past 2 decades, the guidelines produced by the American Association of Orthopedic Surgeons (AAOS) and the American College of Chest Physicians (ACCP) have shown major differences. The report includes ACCP and AAOS guidelines since 2004, current indications for prophylaxis in orthopedic patients, a comparison between ACCP and AAOS guidelines with respect to aspirin therapy for venous thromboembolism prophylaxis in orthopedic patients, the government approved anticoagulants for prophylaxis in the US, Europe, and Japan, and the dosage of anticoagulants for prophylaxis against thrombosis included in the current ACCP guidelines.
Level of Evidence: V; Descriptive review/Expert opinions.
Keywords: Venous thromboembolism prophylaxis; Orthopaedic surgery; Aspirin.